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M94A2977.TXT
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1994-10-25
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Document 2977
DOCN M94A2977
TI Prognostic value of fluconazole response patterns in HIV infected
patients with oropharyngeal candidosis.
DT 9412
AU Diz DP; Miralles C; Ocampo A; Feujoo JF; Sopena B; De la Fuente J;
Martinez C; Xeral-Cies Hospital, Vigo, Spain.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):181 (abstract no. PB0149). Unique
Identifier : AIDSLINE ICA10/94369598
AB OBJECTIVE: To establish a relation between HIV infection evolution and
fluconazole response patterns in HIV-positive patients with
oropharyngeal candidosis. METHODS: In a prospective study a 30
HIV-positive cohort with clinical and microbiological confirmed
oropharyngeal candidosis, received fluconazole therapy (100 mg. per
day). In vitro antifungal susceptibility tests demonstrated lack of
fluconazole resistency. Cultures of mouth swabs were performed at the
end of therapy and two weeks later. During 6 months, a clinical
followi-up of the 30 patients was carried out. RESULTS: Clinical and
microbiological cure was achieved in 26 patients. In 10 of these 26,
cultures remained negative after two weeks (pattern A), most of them
with CD4 > 400/ml. In the remaining 16, cultures detected
microbiological relapse two weeks after treatment (pattern B). In spite
of clinical improvement, treatment failure was observed in 4 patients
(pattern C), all of them with CD4 lymphocyte count < 50/ml. In a 6 month
period, 5 patients presented some AIDS-defining event (4 with pattern B
and 1 with C) and 3 patients died (the 3 remainder with pattern C).
CONCLUSION: The lack of response to fluconazole may represent a complete
failure in the immunitary system and it could be considered a predictor
of fatal evolution. (At the Conference, results after one year of follow
up will be discussed).
DE AIDS-Related Opportunistic Infections/*DRUG THERAPY/IMMUNOLOGY
Candidiasis, Oral/*DRUG THERAPY/IMMUNOLOGY Cohort Studies
Dose-Response Relationship, Drug Fluconazole/*THERAPEUTIC USE Human
Leukocyte Count/DRUG EFFECTS Prognosis Prospective Studies Recurrence
T4 Lymphocytes/IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).